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Reconfiguration of the Respiratory Tract Microbiome to Prevent and Treat Burkholderia Infection

Branda, Steven; Collette, Nicole; Aiosa, Nicole; Garg, Neha; Mageeney, Catherine M.; Williams, Kelly P.; Phillips, Ashlee; Hern, Kelsey; Arkin, Adam; Ricken, Bryce; Wilde, Delaney; Dogra, Sahiba; Humphrey, Brittany; Poorey, Kunal; Courtney, Colleen

New approaches to preventing and treating infections, particularly of the respiratory tract, are needed. One promising strategy is to reconfigure microbial communities (microbiomes) within the host to improve defense against pathogens. Probiotics and prebiotics for gastrointestinal (GI) infections offer a template for success. We sought to develop comparable countermeasures for respiratory infections. First, we characterized interactions between the airway microbiome and a biodefense-related respiratory pathogen (Burkholderia thailandensis; Bt), using a mouse model of infection. Then, we recovered microbiome constituents from the airway and assessed their ability to re-colonize the airway and protect against respiratory Bt infection. We found that microbiome constituents belonging to Bacillus and related genuses frequently displayed colonization and anti-Bt activity. Comparative growth requirement profiling of these Bacillus strains vs Bt enabled identification of candidate prebiotics. This work serves as proof of concept for airway probiotics, as well as a strong foundation for development of airway prebiotics.

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TYPE SAND Report YEAR 2022
DOIOSTI

Rachel Wood Consulting - Viga Span Tables

Bosiljevac, Thomas B.

The purpose and scope of the viga span tables project for Rachel Wood Consulting (RWC) is focused on producing tabulated beam span tables for three species of wood vigas commonly used in New Mexico to allow producers, designers and builders to incorporate vigas into their building designs in a prescriptive manner similar to the span tables for sawn lumber incorporated into the International Residential Code (IRC) or the International Log Builders Association (ILBA) publication. The information provided in this report and the associated viga span tables also attempts to address and clarify questions raised by RWC during their review of the 2018 Los Alamos National Laboratory (LANL) New Mexico Small Business Assistance (NMSBA) program report by August Mosimann pertaining to span lengths, loading, deflection calculations, and log grading certification prior to submitting the span tables to the Construction Industries Division (CID) of New Mexico.

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TYPE Other Report YEAR 2022
OSTIDOI
Results 4701–4725 of 99,299
Results 4701–4725 of 99,299