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Multivariate statistical analysis of concatenated time-of-flight secondary ion mass spectrometry spectral images. Complete description of the sample with one analysis

Analytical Chemistry

Smentkowski, V.S.; Keenan, Michael R.; Ohlhausen, J.A.; Kotula, Paul G.

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) instruments are capable of saving an entire mass spectrum at each pixel of an image, allowing for retrospective analysis of masses that were not selected for analysis during data collection. These TOF-SIMS spectral images contain a wealth of information, but few tools are available to assist the analyst in visualizing the entire raw data set and as a result, most of the data are not analyzed. Automated, nonbiased, multivariate statistical analysis (MVSA) techniques are useful for converting the massive amount of data into a smaller number of chemical components (spectra and images) that are needed to fully describe the TOF-SIMS measurement. Many samples require two back-to-back TOF-SIMS measurements in order to fully characterize the sample, one measurement of the fraction of positively charged secondary ions (positive ion fraction) and one measurement of the fraction of negatively charged secondary ions (negative ion fraction). Each measurement then needs to be individually evaluated. In this paper, we report the first MVSA analysis of a concatenated TOF-SIMS date set comprising positive ion and negative ion spectral images collected on the same region of a sample. MVSA of concatenated data sets provides results that are intuitive and fully describe the sample. The analytical insight provided by MVSA of the concatenated data set was not obtained when either polarity data set was analyzed separately. © 2005 American Chemical Society.

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Implicit Riemann solvers for the Pn equations

Brunner, Thomas A.; Mehlhorn, Thomas A.

The spherical harmonics (P{sub n}) approximation to the transport equation for time dependent problems has previously been treated using Riemann solvers and explicit time integration. Here we present an implicit time integration method for the P n equations using Riemann solvers. Both first-order and high-resolution spatial discretization schemes are detailed. One facet of the high-resolution scheme is that a system of nonlinear equations must be solved at each time step. This nonlinearity is the result of slope reconstruction techniques necessary to avoid the introduction of artifical extrema in the numerical solution. Results are presented that show auspicious agreement with analytical solutions using time steps well beyond the CFL limit.

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Examining tissue differentiation stability through large scale, multi-cellular pathway modeling

May, Elebeoba

Using a multi-cellular, pathway model approach, we investigate the Drosophila sp. segmental differentiation network's stability as a function of initial conditions. While this network's functionality has been investigated in the absence of noise, this is the first work to specifically investigate how natural systems respond to random errors or noise. Our findings agree with earlier results that the overall network is robust in the absence of noise. However, when one includes random initial perturbations in intracellular protein WG levels, the robustness of the system decreases dramatically. The effect of noise on the system is not linear, and appears to level out at high noise levels.

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Perspectives on internet-based frameworks/infrastructures for virtual manufacturing enterprises : a literature review

Virtual manufacturing enterprises (VMEs) are a current, viable, and strategic form of organization for business and other organizations. The perspectives described in this literature review are based upon a basic cluster analysis that identified and classified papers into homogenous subgroups with meaningful themes, or categories. These general themes are related to strategies for business organization and advanced information technologies, virtual industrial/manufacturing organizations/enterprises, frameworks supporting virtual manufacturing enterprises (VMEs), and information technology infrastructures for VMEs.

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Advances in AlGaN-based deep UV LEDs

Crawford, Mary H.; Allerman, A.A.; Fischer, Arthur J.; Bogart, Katherine H.A.; Chow, Weng W.; Wieczorek, Sebastian M.; Kaplar, Robert; Kurtz, S.R.

Materials studies of high Al-content (> 30%) AlGaN epilayers and the performance of AlGaN-based LEDs with emission wavelengths shorter than 300 nm are reported. N-type AlGaN films with Al compositions greater than 30% reveal a reduction in conductivity with increasing Al composition. The reduction of threading dislocation density from the 1-5 x10{sup 10} cm{sup -2} range to the 6-9 x 10{sup 9}cm{sup -2} range results in an improvement of electrical conductivity and Al{sub 0.90}Ga{sub 0.10}N films with n= 1.6e17 cm-3 and f{acute Y}=20 cm2/Vs have been achieved. The design, fabrication and packaging of flip-chip bonded deep UV LEDs is described. Large area (1 mm x 1 mm) LED structures with interdigitated contacts demonstrate output powers of 2.25 mW at 297 nm and 1.3 mW at 276 nm when operated under DC current. 300 f{acute Y}m x 300 f{acute Y}m LEDs emitting at 295 nm and operated at 20 mA DC have demonstrated less than 50% drop in output power after more than 2400 hours of operation. Optimization of the electron block layer in 274 nm LED structures has enabled a significant reduction in deep level emission bands, and a peak quantum well to deep level ratio of 700:1 has been achieved for 300 f{acute Y}m x 300 f{acute Y}m LEDs operated at 100 mA DC. Shorter wavelength LED designs are described, and LEDs emitting at 260 nm, 254nm and 237 nm are reported.

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Frequency and phaselock control of a 3 THz quantum cascade laser

Proposed for publication in Optics Letters.

Reno, John L.

We have locked the frequency of a 3 THz quantum cascade laser (QCL) to that of a far-infrared gas laser with a tunable microwave offset frequency. The locked QCL line shape is essentially Gaussian, with linewidths of 65 and 141 kHz at the -3 and -10 dB levels, respectively. The lock condition can be maintained indefinitely, without requiring temperature or bias current regulation of the QCL other than that provided by the lock error signal. The result demonstrates that a terahertz QCL can be frequency controlled with 1-part-in-108 accuracy, which is a factor of 100 better than that needed for a local oscillator in a heterodyne receiver for atmospheric and astronomic spectroscopy.

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The implications of working set analysis on supercomputing memory hierarchy design

Underwood, Keith D.; Rodrigues, Arun

Supercomputer architects strive to maximize the performance of scientific applications. Unfortunately, the large, unwieldy nature of most scientific applications has lead to the creation of artificial benchmarks, such as SPEC-FP, for architecture research. Given the impact that these benchmarks have on architecture research, this paper seeks an understanding of how they relate to real-world applications within the Department of Energy. Since the memory system has been found to be a particularly key issue for many applications, the focus of the paper is on the relationship between how the SPEC-FP benchmarks and DOE applications use the memory system. The results indicate that while the SPEC-FP suite is a well balanced suite, supercomputing applications typically demand more from the memory system and must perform more 'other work' (in the form of integer computations) along with the floating point operations. The SPEC-FP suite generally demonstrates slightly more temporal locality leading to somewhat lower bandwidth demands. The most striking result is the cumulative difference between the benchmarks and the applications in terms of the requirements to sustain the floating-point operation rate: the DOE applications require significantly more data from main memory (not cache) per FLOP and dramatically more integer instructions per FLOP.

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On the use of titanium nitride as structural material for Nano-Electro-Mechanical Systems (NEMS)

Nielson, Gregory N.

The introduction of new multifunctional materials provides the potential for expanding the realm of microsystems device design and applications. Titanium nitride is identified as an attractive candidate material for use in NEMS applications given its favorable electrical, mechanical and chemical properties thereby enabling its use in high frequency applications and in harsh environments. We demonstrate TiN NEMS structures and low temperature residual stress control of the TiN comprising those structures. Potential applications of TiN as a NEMS structural material are discussed, with particular emphasis on active nanophotonic devices.

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Processing of Lewisite munitions in the explosive destruction system

Didlake, John E.; Shepodd, Timothy J.; Bradshaw, Robert W.

The Explosive Destruction System (EDS) is a transportable system designed to treat chemical munitions. The EDS is transported on an open trailer that provides a mounting surface for major system components and an operator's work platform. The trailer is towed by a prime mover. An explosive containment vessel contains the shock, munition fragments, and the chemical agent during the munition opening process, and then provides a vessel for the subsequent chemical treatment of the agent. A fragmentation suppression system houses the chemical munition and protects the containment vessel from high velocity fragments. An explosive accessing system uses shaped charges to cut the munition open and attack the burster. A firing system detonates the shaped charges. A chemical feed system supplies neutralizing reagents and water to the containment vessel. A waste handling system drains the treated effluent.

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Results 86776–86800 of 99,299
Results 86776–86800 of 99,299