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Investigation of type-I interferon dysregulation by arenaviruses : a multidisciplinary approach

Branda, Catherine; James, Conrad D.; Kozina, Carol L.; Manginell, Ronald; Misra, Milind; Moorman, Matthew W.; Negrete, Oscar N.; Ricken, Bryce; Wu, Meiye

This report provides a detailed overview of the work performed for project number 130781, 'A Systems Biology Approach to Understanding Viral Hemorrhagic Fever Pathogenesis.' We report progress in five key areas: single cell isolation devices and control systems, fluorescent cytokine and transcription factor reporters, on-chip viral infection assays, molecular virology analysis of Arenavirus nucleoprotein structure-function, and development of computational tools to predict virus-host protein interactions. Although a great deal of work remains from that begun here, we have developed several novel single cell analysis tools and knowledge of Arenavirus biology that will facilitate and inform future publications and funding proposals.

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TYPE SAND Report YEAR 2011
DOIOSTI

Mass sensitive, Lorentz-Force actuated, MEMS preconcentrator and chemical sensor

ECS Transactions

Manginell, Ronald P.; Adkins, Douglas R.; Moorman, Matthew W.; Hadizadeh, Rameen; Copic, Davor; Porter, Daniel; Anderson, John M.; Wheeler, David R.; Pfeifer, Kent B.; Rumpf, Arthur

The mass-sensitive smart preconcentrator (SPC) consists of a Lorentz-Force-actuated MEMS resonator with an integral heater and surface coating for the collection of chemical analytes. Control circuitry is used to drive the SPC to resonance and measure its oscillation frequency. The frequency shift produced by adsorption of analyte on the SPC surface is inversely proportional to the mass of analyte collected. Thus, the SPC can measure when it has collected sufficient analyte for a downstream detection system. The limit of detection (LOD) of the SPC is less than 50 ppb for DMMP (dimethyl-methyl- phosphonate). At 1 ppm, less than 1 second collection of DMMP is sufficient to trigger analysis. An analytical model of operation of the SPC is used to predict the motion of the paddle and the shear modulus of silicon. © The Electrochemical Society.

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TYPE Conference YEAR 2009
ScopusOSTI

Microfabricated chip for calibration of field instruments

2007 IEEE Conference on Technologies for Homeland Security: Enhancing Critical Infrastructure Dependability

Moorman, Matthew W.; Robinson, Alex; Manginell, Ronald; Tappan, Alexander S.; Linker, Kevin L.

Accurate, periodic calibration is required to operate IMS, GC, and portal security systems with maximum efficiency, surety, and operator confidence. To this end, we are presently developing a microfabricated device for on-demand calibration of fleldable contraband detection instruments. Using robotically-assisted picoliter dispensing methods, precise nanogram or larger amounts of calibration compound(s) are placed on micron-sized bridge structures. Resistively heating these structures delivers precisely quantified low-levels of calibration compounds to the detector systems. This provides reliable calibration for identification and quantification of explosives, narcotics, and other contraband. © 2007 IEEE.

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TYPE Conference YEAR 2007
OSTIScopus
Results 76–100 of 105
Results 76–100 of 105