Biological Science

Wearable sensor to monitor ‘last line of defense’ antibiotic

Preventing collateral damage in cancer treatment

Sandia has a dynamic biological research mission that addresses important national security challenges. Sandia’s research in two strategic areas—biomanufacturing and biodefense—aims to provide biological solutions to critical challenges in energy and homeland security.

Why Our Work Matters

Sandia’s research in these areas:

Develops a deep understanding of biological systems and the ability to predict and control their behaviors
Ensures energy security
Protects our environment
Strengthens our nation’s defense against biological threats

Our Unique Value

Our researchers work in multidisciplinary teams that integrate strengths in synthetic biology and gene-editing, infectious disease technology, computational biology and bioinformatics, microfluidics and microsystems, and pre-treatment science and engineering. Drawing on the combined knowledge and ideas of a larger community of experts allows Sandia to develop diverse capabilities and enable powerful solutions.

Recent Highlights

Confirming dismantlement of nuclear warheads while protecting sensitive information

When it comes to nuclear arms control, verification is essential. By detecting unique metastable radionuclide signatures...

Developing engineered probiotics to combat respiratory infections

Sandia researchers are focused on protecting soldiers and citizens from biological threats by creating innovative solutions...

Improving understanding of microbial roles in permafrost carbon release

As permafrost thaws, it exposes ancient organic matter that microbes can use as fuel. This process...

Lignin processing with machine learning approaches

The schematic diagram for screening of solvents for lignin dissolution. Using ionic liquids (IL) to break...

RUBISCO - Soil carbon working group: Collaborative science to enhance predictive understanding.

Project Description Current Energy Earth System Models (ESM) representation of soil organic matter (SOM) and its...

Algae is shown growing from underneath the water.

Microbiome editing to improve economic viability of algae growth as a feedstock

The major challenge with using algae as a feedstock is growing it economically, which hinges strongly...

A circular diagram with the research project goal broken into three objectives being worked on by researchers.

Biometric calcification for carbon sequestration from seawater

An integrated data science and experimental approach is being taken to the challenges of direct capture...

Umakant Mishra stands at the bottom of Mount Everest.

Improving/testing machine learning methods for benchmarking soil carbon dynamics representation of land surface models

Representation of soil organic carbon (SOC) dynamics in Earth system models (ESM) is a key source...

Image of a male scientist looking at a test tube

High-quality feedstocks address sustainability challenges associated with rising global demand for protein

Ryan Davis, a principal member of Sandia’s technical staff in Bioresource and Environmental Security, and his...

Secure bioscience design project expands CRISPR molecular toolkit

The Intrinsic Control for Genome and Transcriptome Editing in Communities (InCoGenTEC) project team, exploiting the CRISPR-associated...

Catherine Mageeney is seeking a “kill shot” in bacterial pathogens

Catherine Mageeney, a senior member of Sandia’s technical staff in bioengineering and biotechnology, has expertise in...

Biological Science Related Research Facilities

Applied Biosciences Lab (ABL)

The ABL located in Livermore, CA focuses on energy security, confronting the risks of global warming and biosecurity research focused on reducing threats from infectious diseases and biological weapons.

Facility for Acceptance, Calibration, and Testing (FACT Site)

The FACT site provides the equipment and seismically quiet surroundings required for testing infrasound and seismic sensors, instrumentation, and monitoring systems.

Joint BioEnergy Institute (JBEI)

JBEI is a DOE Bioenergy Research Center dedicated to developing advanced biofuels—liquid fuels derived from the solar energy stored in plant biomass that can replace gasoline, diesel, and jet fuels.

Related Intellectual Property

Fentanyl Analog Independent Detection (FAID)

Bioscience & Medical • Portable fentanyl detection technology offers unmatched sensitivity and enhanced safety for first responders, military, and law enforcement personnel Business Problem Fentanyl, a synthetic opioid, is the leading cause of death...

New Method to Convert LDPE Plastic Waste to Useful Chemicals

Bioscience & Medical • Degrade plastic waste materials to valuable chemicals, food sources and renewable energy related products using a catalytic oxidative process. Transforming plastic waste to value-added components such as fuels, chemicals, or...

Brain-Targeting Nanobodies

Bioscience & Medical • Nanobodies capable of penetrating the Blood-Brain Barrier (BBB) can act aseffective shuttles to convey chemical and biological therapeutics with targetedspecificity to the central nervous system (CNS). The biomedical community has...

Comprehensive Testing of Respiratory Personal Protective Equipment

Bioscience & Medical • New and improved approaches to rapidly test and certify respiratory personal protective equipment (PPE) can ensure widespread availability and reliable protection from airborne pathogens. Business Problem During the COVID-19 pandemic,...

Tinker Tailoring Lignin

Bioscience & Medical • A method to generate oxidized lignin with specified carboxylic acid content and molecular weight that can be used in various types of polymer products. The valorization of lignin has faced...

Lung-Targeting Nanobodies and Purification Methods

Bioscience & Medical • A new approach for combating infectious disease at lower dose frequencies and amounts by directly delivering enhanced potency therapeutics Immunohistochemistry (IHC) readout of nanobodylocalization and specificity within the lung tissue...

Therapeutic Phage Cocktails

Bioscience & Medical • Engineered viruses and phages capable of targeting pathogenic bacterium Pathogenic bacteria have been gradually developing resistance to known antibiotics, which could thwart the effort of preventing catastrophic bacterial outbreak infections....

Analog Neuron Device for Brain-Computer Interface

Bioscience & Medical • A computing hardware approach that aspires to emulate the brain. Ruthenium-based Prussian blue analogue for artificial synapses have transformational potential in neuroprosthetics, brain disease diagnostics, and ubiquitous edge computing. In...

RAPTR N95: Rapidly Producible, Reusable N95 Respirator

Bioscience & Medical • Sandia National Laboratories in collaboration with Mayo Clinic has developed a rapidly producible, reusable N95 respirator mask designed for medical use Significant shortages in the supply and availability of medical-grade...

RuBisCo

Bioscience & Medical • A high-quality feedstock to address scaling and sustainability challenges associated with the growing global demand for protein Global demand for high quality digestible protein is expected to substantially outpace population...

Targeted Antibody Therapeutics

Bioscience & Medical • Highly potent SARS-CoV-2 antibodies show pre-clinical efficacy and delayed disease progression The COVID-19 pandemic has emphasized the need for the global community to rapidly acquire a diverse arsenal of prevention...

ViralFx

Bioscience & Medical • ViralFx is an integrated approach to the diagnosis and treatment of SARS-CoV-2 that is accurate, rapid, repeatable, and easily deployed In pandemic scenarios, the capacity to complete laboratory diagnostic tests...

RetSynth Software

Bioscience & Medical • RetSynth is a comprehensive tool for rapidly identifying all optimal and sub-optimal pathways for the bioproduction of high value target compounds The successful biological production of high value target compounds...

Quenching of Unincorporated Amplification Signal Reporters (QUASR)

Bioscience & Medical • Sandia’s QUASR modification to LAMP helps satisfy the requirements for a simple, robust, and inexpensive point-of-care deployed diagnostic device Rapid changes in how the world must react to pandemics has...

RNA-Targeting CAS9 System for Controlling Viruses

Bioscience & Medical • CRISPR Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9) is a protein that plays an important role in immunological defense of bacteria against DNA viruses. A CRISPR-Cas based...

SmartLAMP

Bioscience & Medical • Researchers at Sandia National Laboratories have developed a smartphone-controlled, battery-operated point-of-care diagnostic device that weighs under a pound, costs as little as $100 and can detect Zika and other vector-borne...

Large Field of View, 3D X-ray Phase Contrast Imaging System

Bioscience & Medical • A high-sensitivity X-ray Phase Contrast Imaging system for non-destructive 2D radiography and 3D tomography of low-density composite materials Sandia National Laboratories has developed a high-sensitivity X-ray Phase Contrast Imaging (XPCI)...

Automated Gloving System

Bioscience & Medical • Engineers at Sandia Labs have invented the only fully Automated Gloving System to prepare and dispense gloves for quick application while reducing the potential for contact contamination. Dust and particulate...

One-Pot Bioconversion of Distiller's Grains to Advanced Biofuels

Bioscience & Medical • Increases in bioethanol production throughout the US has led to an increase in the process co-product—distillers grains with solubles (DGS). DGS can be used to feed livestock, however, product inconsistency...

Miniaturized Chemical Detectors for Point-of-Care Diagnosis

Bioscience & Medical • Sandia’s mini-PDID makes it possible to diagnose illnesses by identifying volatile organic compounds (VOCs) associated with certain diseases and infections on a patient’s breath or in the headspace of biological...

Bacteriophage Host-Range Expansion

Bioscience & Medical • Decades of widespread antibiotic use has created antibiotic-resistant strains of bacteria that are becoming increasingly difficult to treat. In 2006, the Food and Drug Administration (FDA) approved the use of...

SWick Zoom

Bioscience & Medical • Traditional zoom imaging requires the mechanical movement of two or more optical elements along the optical axis, as is done in 35mm cameras or conventional, variable-power riflescopes. Adaptive zoom is...

Synthesis of Uniform Magnetic Nanoparticles

Bioscience & Medical • Highly uniform magnetic nanoparticles are highly desirable for numerous applications including medical imaging, chemical manufacturing, and development of drugs in the pharmaceutical industry. Currently, achieving nanoparticles with a small size...

Microscale Immune and Cell Analysis (MICA)

Bioscience & Medical • Researchers at Sandia National Laboratories have created a sophisticated, integrated platform for single-cell manipulation and interrogation. Called Microscale Immune and Cell Analysis (MICA), this platform represents a revolutionary breakthrough in...

The µChemLab™ Bio Detector

Bioscience & Medical • Sandia's chemical analysis system can rapidly detect and analyze toxic agents such as bacteria, viruses, and protozoa Sandia National Laboratories has developed a compact, hand-held detection system that places the...

SpinDx™: Point-of-Care Diagnostics Using Centrifugal Microfluidics

Bioscience & Medical • Researchers at Sandia National Laboratories have developed an innovative technique for conducting simultaneous multiplexed immunoassays and white blood cell counts from a single finger prick of whole blood with less...

Rapid Automated Point-of-Care System (RapiDx)

Bioscience & Medical • The Rapid, Automated Point-of-Care System (RapiDx) developed by Sandia National Laboratories is a portable diagnostic instrument. RapiDx quickly measures--with high sensitivity--disease and toxin biomarkers in human biological samples (e.g., blood,...

Miniature High-Voltage Power Supply and Miniature High-Voltage Controller

Bioscience & Medical • Many microfluidics systems use electrokinetic (EK) pumping of fluid. These applications generally require high voltage at a low current. Sandia has developed two custom power supply designs with miniaturization, modularity,...

Microfluidic Polymer Valves

Bioscience & Medical • In a technological breakthrough, Sandia researchers have developed polymer microvalves to allow fluids to be shuttled as easily in microfluidic chips as they are on a laboratory benchtop. The valves...

Trojan Horse Project: Biorefinery in a Plant

Bioscience & Medical • Sandia researchers have developed a technology that could potentially turn agricultural waste, weeds, and other plant products that are typically discarded or destroyed into fuel. The idea is to create...

Semipermeable Membranes for Micromachined Silicon Surfaces

Bioscience & Medical • Semipermeable silicon nitride membranes developed using an etch process for co-manufacture on a micromachined silicon surface There is a need for a co-fabricated filtration system for enhancement of reliability and...

Patent Title	Patent Number	Grant Date
Real-time patch-clamp sensing of transport across a barrier tissue	US12540938B1	02/03/2026 New!
Real-time patch-clamp sensing of transport across a barrier tissue	US12540938B1	02/03/2026 New!
Multiplanar planar electromagnetic array	US12523654B1	01/13/2026
Lung-targeting single-domain antibodies and purification methods	US12421306B1	09/23/2025
Reusable filtering face mask	US12364883B2	07/22/2025
Reusable filtering face mask	US12364883B2	07/22/2025
Modified yeast microorganisms to increase yield of 3-hydropropionic acid	US12215373B1	02/04/2025
Enrichment of amino acids from biomass residuum	US12203116B2	01/21/2025
Enrichment of amino acids from biomass residuum	US12203116B2	01/21/2025
Sensor discriminators and methods for detecting electrical property changes in a metal organic framework	US12203911B1	01/21/2025
Respirator test system	US12161894B1	12/10/2024
Respirator test system	US12161894B1	12/10/2024
Brain-targeting single domain antibodies and purification methods	US12098200B1	09/24/2024
Multivalent anti-SARS-CoV-2 nanobodies	US12098186B1	09/24/2024
Brain-targeting single domain antibodies and purification methods	US12098200B1	09/24/2024
SARS-CoV-2 variant nanobodies and constructs comprising such nanobodies	US12091446B1	09/17/2024
Acoustic wave resonator with active shunt capacitance cancellation and systems thereof	US12084708B1	09/10/2024
Acoustic wave resonator with active shunt capacitance cancellation and systems thereof	US12084708B1	09/10/2024
Acoustic wave resonator with active shunt capacitance cancellation and systems thereof	US12084708B1	09/10/2024
Alkyl dialkoxyalkanoates as bioderived, high cetane diesel fuels	US12077719B2	09/03/2024
Alkyl dialkoxyalkanoates as bioderived, high cetane diesel fuels	US12077719B2	09/03/2024
Apparatus and methods for sample analysis with multi-gradient microfluidics	US12070751B1	08/27/2024
Coronavirus neutralizing humanized antibodies and uses thereof	US12024551B1	07/02/2024
Devices for studying plant-fungus interactions and for imaging plant roots	US11993764B2	05/28/2024
Real-time patch-clamp sensing of transport across a barrier tissue	US11885793B1	01/30/2024
Real-time patch-clamp sensing of transport across a barrier tissue	US11885793B1	01/30/2024
Sensor discriminators and methods for detecting electrical property changes in a metal organic framework	US11867677B1	01/09/2024
Vector measurements using a pulsed, optically pumped atomic magnetometer	US11841404B1	12/12/2023
Vector measurements using a pulsed, optically pumped atomic magnetometer	US11841404B1	12/12/2023
Optically pumped, radio-frequency atomic magnetometry with feedback stabilization	US11821966B1	11/21/2023
Optically pumped, radio-frequency atomic magnetometry with feedback stabilization	US11821966B1	11/21/2023
Methods and systems for opioid detection	US11733217B1	08/22/2023
Methods and systems for opioid detection	US11733217B1	08/22/2023
Multifunctional RF limiting amplifier	US11722106B1	08/08/2023
Multifunctional RF limiting amplifier	US11722106B1	08/08/2023
CRISPR-Cas based system for targeting single-stranded sequences	US11661599B1	05/30/2023
Small molecule inhibitors for treatment of alpha viruses	US11564919B1	01/31/2023
Small molecule inhibitors for treatment of alpha viruses	US11564919B1	01/31/2023
Methods of producing lipid-derived compounds and host cells thereof	US11560576B1	01/24/2023
Methods of producing lipid-derived compounds and host cells thereof	US11560576B1	01/24/2023
Microfluidic package and method of making the same	US11554369B2	01/17/2023
Microfluidic package and method of making the same	US11554369B2	01/17/2023
Microfluidic package and method of making the same	US11554369B2	01/17/2023
Optically pumped gradient magnetometer	US11543474B1	01/03/2023
Optically pumped gradient magnetometer	US11543474B1	01/03/2023
Engineering RuBisCo for food safety	US11518989B1	12/06/2022
Engineering RuBisCo for food safety	US11518989B1	12/06/2022
Engineering RuBisCo for food safety	US11518989B1	12/06/2022
Alkyl dialkoxyalkanoates as bioderived, high cetane diesel fuels	US11492565B1	11/08/2022
Alkyl dialkoxyalkanoates as bioderived, high cetane diesel fuels	US11492565B1	11/08/2022
Endpoint detection of amplified nucleic acids	US11473141B2	10/18/2022
Endpoint detection of amplified nucleic acids	US11473141B2	10/18/2022
Endpoint detection of amplified nucleic acids	US11473141B2	10/18/2022
Engineered hosts with exogenous ligninase and uses thereof	US11453895B1	09/27/2022
Engineered hosts with exogenous ligninase and uses thereof	US11453895B1	09/27/2022
Engineered hosts with exogenous ligninase and uses thereof	US11453895B1	09/27/2022
Lipid composition for the delivery of therapeutic cargos	US11433121B1	09/06/2022
Lipid composition for the delivery of therapeutic cargos	US11433121B1	09/06/2022
Solid-state tuning behavior in acoustic resonators	US11405014B1	08/02/2022
Solid-state tuning behavior in acoustic resonators	US11405014B1	08/02/2022
Electrochemical detection of gas phase chemicals	US11378547B1	07/05/2022
Real time autonomous surveillance of pathogens	US11366116B1	06/21/2022
Real time autonomous surveillance of pathogens	US11366116B1	06/21/2022
Real time autonomous surveillance of pathogens	US11366116B1	06/21/2022
Enrichment of amino acids from biomass residuum	US11326193B1	05/10/2022
Enrichment of amino acids from biomass residuum	US11326193B1	05/10/2022
Biochemical upgrading of high-protein biomass and grain products	US11312978B2	04/26/2022
Biochemical upgrading of high-protein biomass and grain products	US11312978B2	04/26/2022
Compounds that induce octane overboosting	US11225622B1	01/18/2022
Compounds that induce octane overboosting	US11225622B1	01/18/2022
Functionalized coating polymers and uses thereof	US11203702B1	12/21/2021
Functionalized coating polymers and uses thereof	US11203702B1	12/21/2021
Fatty acid derived alkyl ether fuels for compression ignition	US11193075B1	12/07/2021
Fatty acid derived alkyl ether fuels for compression ignition	US11193075B1	12/07/2021
Check valves for microfluidic systems and methods thereof	US11130129B2	09/28/2021
Check valves for microfluidic systems and methods thereof	US11130129B2	09/28/2021
Check valves for microfluidic systems and methods thereof	US11130129B2	09/28/2021
Promoters and uses thereof	US11098306B1	08/24/2021
Promoters and uses thereof	US11098306B1	08/24/2021
Promoters and uses thereof	US11098306B1	08/24/2021
Therapeutic phages and methods thereof	US11066691B1	07/20/2021
Therapeutic phages and methods thereof	US11066691B1	07/20/2021
System, algorithm, and method using short pulse interrogation with neutrons to detect and identify matter	US11061164B1	07/13/2021
Lipid-coated particles for treating viral infections	US11045554B1	06/29/2021
Lipid-coated particles for treating viral infections	US11045554B1	06/29/2021
Tunable metal-organic framework compositions and methods thereof	US11007516B1	05/18/2021
Tunable metal-organic framework compositions and methods thereof	US11007516B1	05/18/2021
Tunable metal-organic framework compositions and methods thereof	US11007516B1	05/18/2021
Neural interface methods and apparatus to provide artificial sensory capabilities to a subject	US10993665B1	05/04/2021
Neural interface methods and apparatus to provide artificial sensory capabilities to a subject	US10993665B1	05/04/2021
Modular assemblies and systems for cell cultures and methods thereof	US10988723B1	04/27/2021
Modular assemblies and systems for cell cultures and methods thereof	US10988723B1	04/27/2021
Protein and nucleic acid detection for microfluidic devices	US10981174B1	04/20/2021
Protein and nucleic acid detection for microfluidic devices	US10981174B1	04/20/2021
Protein and nucleic acid detection for microfluidic devices	US10981174B1	04/20/2021
Terpene synthases for biofuel production and methods thereof	US10947563B2	03/16/2021
Shape-preserving polymeric replication of biological matter	US10947349B2	03/16/2021
Shape-preserving polymeric replication of biological matter	US10947349B2	03/16/2021
Terpene synthases for biofuel production and methods thereof	US10947563B2	03/16/2021
Method to synthesize nanoparticle supercrystals	US10947116B2	03/16/2021
Octane hyperboosting in fuel blends	US10899988B1	01/26/2021
Octane hyperboosting in fuel blends	US10899988B1	01/26/2021
Conversion of lignin into a water-soluble polyacid using a MOF catalyst	US10800891B1	10/13/2020
Conversion of lignin into a water-soluble polyacid using a MOF catalyst	US10800891B1	10/13/2020
Detection of active and latent infections with microfluidic devices and systems thereof	US10786811B1	09/29/2020
Detection of active and latent infections with microfluidic devices and systems thereof	US10786811B1	09/29/2020
Detection of active and latent infections with microfluidic devices and systems thereof	US10786811B1	09/29/2020
Apparatus, method and system for imaging and utilization of SEM charged particles	US10770262B1	09/08/2020
Apparatus, method and system for imaging and utilization of SEM charged particles	US10770262B1	09/08/2020
Microfluidic platform for multiplexed detection in single cells and methods thereof	US10731205B2	08/04/2020
Microfluidic platform for multiplexed detection in single cells and methods thereof	US10731205B2	08/04/2020
Microfluidic platform for multiplexed detection in single cells and methods thereof	US10731205B2	08/04/2020
Endpoint detection of amplified nucleic acids	US10724091B1	07/28/2020
Endpoint detection of amplified nucleic acids	US10724091B1	07/28/2020
Endpoint detection of amplified nucleic acids	US10724091B1	07/28/2020
Microfluidic package and method of making the same	US10717079B2	07/21/2020
Microfluidic package and method of making the same	US10717079B2	07/21/2020
Microfluidic package and method of making the same	US10717079B2	07/21/2020
Miniaturized pulsed discharge ionization detector, non-radioactive ionization sources, and methods thereof	US10697934B2	06/30/2020
Miniaturized pulsed discharge ionization detector, non-radioactive ionization sources, and methods thereof	US10697934B2	06/30/2020
Biochemical upgrading of high-protein biomass and grain products	US10683519B1	06/16/2020
Biochemical upgrading of high-protein biomass and grain products	US10683519B1	06/16/2020
Fluid delivery manifolds and microfluidic systems	US10627366B2	04/21/2020
Methods for treating diseases related to the wnt pathway	US10624949B1	04/21/2020
Methods for treating diseases related to the wnt pathway	US10624949B1	04/21/2020
Methods for treating diseases related to the wnt pathway	US10624949B1	04/21/2020
Fluid delivery manifolds and microfluidic systems	US10627366B2	04/21/2020
Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid	US10590477B2	03/17/2020
Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid	US10590477B2	03/17/2020
Shape-preserving polymeric replication of biological matter	US10538632B1	01/21/2020
Shape-preserving polymeric replication of biological matter	US10538632B1	01/21/2020
Check valves for microfluidic systems and methods thereof	US10478818B1	11/19/2019
Check valves for microfluidic systems and methods thereof	US10478818B1	11/19/2019
Check valves for microfluidic systems and methods thereof	US10478818B1	11/19/2019
Non-contact temperature control system for microfluidic devices	US10406528B1	09/10/2019
Non-contact temperature control system for microfluidic devices	US10406528B1	09/10/2019
Non-contact temperature control system for microfluidic devices	US10406528B1	09/10/2019
Terpene synthases for biofuel production and methods thereof	US10400254B1	09/03/2019
Terpene synthases for biofuel production and methods thereof	US10400254B1	09/03/2019
Nonaqueous redox flow battery electrolyte comprising an ionic liquid with a metal cation coordinated to redox-active ligands	US10305133B2	05/28/2019
Linear peptides that mimic structural epitopes for antibody assays	US10267788B1	04/23/2019
Linear peptides that mimic structural epitopes for antibody assays	US10267788B1	04/23/2019
Shear horizontal surface acoustic wave (SH-SAW) resonators and arrays thereof	US10261078B2	04/16/2019
Shear horizontal surface acoustic wave (SH-SAW) resonators and arrays thereof	US10261078B2	04/16/2019
Shear horizontal surface acoustic wave (SH-SAW) resonators and arrays thereof	US10261078B2	04/16/2019
Miniaturized pulsed discharge ionization detector, non-radioactive ionization sources, and methods thereof	US10197532B1	02/05/2019
Miniaturized pulsed discharge ionization detector, non-radioactive ionization sources, and methods thereof	US10197532B1	02/05/2019
Trajectory-based triggering system for hyperspectral imaging flow cytometer	US10180398B2	01/15/2019
Trajectory-based triggering system for hyperspectral imaging flow cytometer	US10180398B2	01/15/2019
Microsampler and method of making the same	US10161835B1	12/25/2018
Microsampler and method of making the same	US10161835B1	12/25/2018
Microsampler and method of making the same	US10161835B1	12/25/2018
Sealed micro gas chromatography columns and methods thereof	US10151732B1	12/11/2018
Sealed micro gas chromatography columns and methods thereof	US10151732B1	12/11/2018
Sealed micro gas chromatography columns and methods thereof	US10151732B1	12/11/2018
Tandem biochemical and thermochemical conversion of algal biomass	US10077454B1	09/18/2018
Tandem biochemical and thermochemical conversion of algal biomass	US10077454B1	09/18/2018
Detection of bioagents using a shear horizontal surface acoustic wave biosensor	US10031135B2	07/24/2018
Detection of bioagents using a shear horizontal surface acoustic wave biosensor	US10031135B2	07/24/2018
Atomic magnetometer with multiple spatial channels	US9995800B1	06/12/2018
High-temperature, adhesive-based microvalves and uses thereof	US9995411B1	06/12/2018
Atomic magnetometer with multiple spatial channels	US9995800B1	06/12/2018
High-temperature, adhesive-based microvalves and uses thereof	US9995411B1	06/12/2018
Methods of expanding bacteriophage host-range and bacteriophage produced by the methods	US9988608B1	06/05/2018
Methods of expanding bacteriophage host-range and bacteriophage produced by the methods	US9988608B1	06/05/2018
Microfluidic platform for multiplexed detection in single cells and methods thereof	US9957554B1	05/01/2018
Microfluidic platform for multiplexed detection in single cells and methods thereof	US9957554B1	05/01/2018
Microfluidic platform for multiplexed detection in single cells and methods thereof	US9957554B1	05/01/2018
Optoelectronic system and apparatus for connection to biological systems	US9907496B1	03/06/2018
Optoelectronic system and apparatus for connection to biological systems	US9907496B1	03/06/2018
Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid	US9803238B1	10/31/2017
Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid	US9803238B1	10/31/2017
System and method for detecting components of a mixture including a valving scheme for competition assays	US9766230B1	09/19/2017
System and method for detecting components of a mixture including a valving scheme for competition assays	US9766230B1	09/19/2017
Massively parallel diffuse optical tomography	US9750413B2	09/05/2017
Massively parallel diffuse optical tomography	US9750413B2	09/05/2017
Resonant surface acoustic wave chemical detector	US9726646B1	08/08/2017
Metal-organic framework catalysts for selective cleavage of aryl-ether bonds	US9718748B1	08/01/2017
System and method for detecting components of a mixture including a valving scheme for competition assays	US9702871B1	07/11/2017
System and method for detecting components of a mixture including a valving scheme for competition assays	US9702871B1	07/11/2017
Catheterized plasma X-ray source	US9681846B1	06/20/2017
Catheterized plasma X-ray source	US9681846B1	06/20/2017
Metal-organic frameworks for adsorption and separation of noble gases	US9662632B1	05/30/2017
Metal-organic frameworks for adsorption and separation of noble gases	US9662632B1	05/30/2017
Fluid delivery manifolds and microfluidic systems	US9579649B2	02/28/2017
Fluid delivery manifolds and microfluidic systems	US9579649B2	02/28/2017
Neural interface methods and apparatus to provide artificial sensory capabilities to a subject	US9549704B1	01/24/2017
Neural interface methods and apparatus to provide artificial sensory capabilities to a subject	US9549704B1	01/24/2017
Miniature acoustic wave lysis system and uses thereof	US9512421B1	12/06/2016
Miniature acoustic wave lysis system and uses thereof	US9512421B1	12/06/2016
Low-temperature nanosolders	US9463532B2	10/11/2016
Miniaturized photoacoustic spectrometer	US9410931B1	08/09/2016
Colorometric detection of water using MOF-polymer films and composites	US9347923B1	05/24/2016
Colorometric detection of water using MOF-polymer films and composites	US9347923B1	05/24/2016
Multiplexed microfluidic approach for nucleic acid enrichment	US9322014B1	04/26/2016
Multiplexed microfluidic approach for nucleic acid enrichment	US9322014B1	04/26/2016
Self-shielding flex-circuit drift tube, drift tube assembly and method of making	US9324550B1	04/26/2016
Toxin activity assays, devices, methods and systems therefor	US9304128B1	04/05/2016
Toxin activity assays, devices, methods and systems therefor	US9304128B1	04/05/2016
Sub-wavelength antenna enhanced bilayer graphene tunable photodetector	US9293627B1	03/22/2016
Sub-wavelength antenna enhanced bilayer graphene tunable photodetector	US9293627B1	03/22/2016
Method for the electro-addressable functionalization of electrode arrays	US9212430B1	12/15/2015
Trace detection of analytes using portable raman systems	US9194805B2	11/24/2015
Multifunctional thin film surface	US9157161B1	10/13/2015
Multifunctional thin film surface	US9157161B1	10/13/2015
Multifunctional thin film surface	US9157161B1	10/13/2015
Microfluidic device for acoustic cell lysis	US9096823B1	08/04/2015
Microfluidic device for acoustic cell lysis	US9096823B1	08/04/2015
Methods and materials for deconstruction of biomass for biofuels production	US9024111B1	05/05/2015
Methods and materials for deconstruction of biomass for biofuels production	US9024111B1	05/05/2015
Microfluidic hubs, systems, and methods for interface fluidic modules	US8940147B1	01/27/2015
Microfluidic hubs, systems, and methods for interface fluidic modules	US8940147B1	01/27/2015
Haptic device for telerobotic surgery	US8924009B2	12/30/2014
Haptic device for telerobotic surgery	US8924009B2	12/30/2014
Materials, methods and devices to detect and quantify water vapor concentrations in an atmosphere	US8904850B1	12/09/2014
Materials, methods and devices to detect and quantify water vapor concentrations in an atmosphere	US8904850B1	12/09/2014
Methods, microfluidic devices, and systems for detection of an active enzymatic agent	US8871496B1	10/28/2014
Methods, microfluidic devices, and systems for detection of an active enzymatic agent	US8871496B1	10/28/2014
Methods, microfluidic devices, and systems for detection of an active enzymatic agent	US8871496B1	10/28/2014
Dynamic tuning of chemiresistor sensitivity using mechanical strain	US8846406B1	09/30/2014
Dynamic tuning of chemiresistor sensitivity using mechanical strain	US8846406B1	09/30/2014
Microelectroporation device for genomic screening	US8828736B2	09/09/2014
Microelectroporation device for genomic screening	US8828736B2	09/09/2014
Microelectroporation device for genomic screening	US8828736B2	09/09/2014
Detection of electrophilic and nucleophilic chemical agents	US8802444B1	08/12/2014
Capacitive chemical sensor	US8736000B1	05/27/2014
Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis	US8728290B1	05/20/2014
Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis	US8728290B1	05/20/2014
Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis	US8728290B1	05/20/2014
Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis	US8728290B1	05/20/2014
Screening system and method of using same	US8695443B1	04/15/2014
Dual-etalon cavity ring-down frequency-comb spectroscopy with broad band light source	US8693004B2	04/08/2014
Dual-etalon cavity ring-down frequency-comb spectroscopy with broad band light source	US8693004B2	04/08/2014
Hyperspectral stimulated emission depletion microscopy and methods of use thereof	US8686363B1	04/01/2014
Hyperspectral stimulated emission depletion microscopy and methods of use thereof	US8686363B1	04/01/2014
Optically transduced MEMS magnetometer	US8674689B1	03/18/2014
Optically transduced MEMS magnetometer	US8674689B1	03/18/2014
High-frequency shear-horizontal surface acoustic wave sensor	US8669688B1	03/11/2014
High-frequency shear-horizontal surface acoustic wave sensor	US8669688B1	03/11/2014
Coaxial microreactor for particle synthesis	US8563325B1	10/22/2013
Stress-tuned conductor-polymer composite for use in sensors	US8562878B1	10/22/2013
Stress-tuned conductor-polymer composite for use in sensors	US8562878B1	10/22/2013
Coaxial microreactor for particle synthesis	US8563325B1	10/22/2013
Preconcentrator with high volume chiller for high vapor pressure particle detection	US8561483B1	10/22/2013
Apparatus and method for measuring single cell and sub-cellular photosynthetic efficiency	US8481974B1	07/09/2013
Apparatus and method for measuring single cell and sub-cellular photosynthetic efficiency	US8481974B1	07/09/2013
Heterodyne photomixer spectrometer with receiver photomixer driven at different frequency than source photomixer	US8482739B1	07/09/2013
Method of detecting cancer in a single cell using mitochondrial correlation microscopy	US8472752B1	06/25/2013
Method of detecting cancer in a single cell using mitochondrial correlation microscopy	US8472752B1	06/25/2013
Method of detecting cancer in a single cell using mitochondrial correlation microscopy	US8472752B1	06/25/2013
Method of detecting cancer in a single cell using mitochondrial correlation microscopy	US8472752B1	06/25/2013
Materials and methods for stabilizing nanoparticles in salt solutions	US8461300B2	06/11/2013
Materials and methods for stabilizing nanoparticles in salt solutions	US8461300B2	06/11/2013
High-frequency shear-horizontal surface acoustic wave sensor	US8436509B1	05/07/2013
High-frequency shear-horizontal surface acoustic wave sensor	US8436509B1	05/07/2013
System for particle concentration and detection	US8398839B1	03/19/2013
System for particle concentration and detection	US8398839B1	03/19/2013
Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis	US8329016B1	12/11/2012
Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis	US8329016B1	12/11/2012
Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis	US8329016B1	12/11/2012
Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis	US8329016B1	12/11/2012
Portable dual field gradient force multichannel flow cytometer device with a dual wavelength low noise detection scheme	US8293089B1	10/23/2012
Portable dual field gradient force multichannel flow cytometer device with a dual wavelength low noise detection scheme	US8293089B1	10/23/2012
Portable dual field gradient force multichannel flow cytometer device with a dual wavelength low noise detection scheme	US8293089B1	10/23/2012
Detection of electrophilic and nucleophilic chemical agents	US8247554B1	08/21/2012
Atomic magnetometer	US8212556B1	07/03/2012
Atomic magnetometer	US8212556B1	07/03/2012
Method for detecting cancer in a single cell using mitochondrial correlation microscopy	US8131112B1	03/06/2012
Method for detecting cancer in a single cell using mitochondrial correlation microscopy	US8131112B1	03/06/2012
Method for detecting cancer in a single cell using mitochondrial correlation microscopy	US8131112B1	03/06/2012
Method for detecting cancer in a single cell using mitochondrial correlation microscopy	US8131112B1	03/06/2012
Method and apparatus for detecting an analyte	US8065904B1	11/29/2011
Method and apparatus for detecting an analyte	US8065904B1	11/29/2011
Information-based self-organization of sensor nodes of a sensor network	US8022987B2	09/20/2011
Information-based self-organization of sensor nodes of a sensor network	US8022987B2	09/20/2011
Electrode array for neural stimulation	US8000804B1	08/16/2011
Electrode array for neural stimulation	US8000804B1	08/16/2011
Simultaneous sample manipulation and sensing using surface acoustic waves	US7878063B1	02/01/2011
Simultaneous sample manipulation and sensing using surface acoustic waves	US7878063B1	02/01/2011
System and method for statistically monitoring and analyzing sensed conditions	US7877234B1	01/25/2011
System and method for statistically monitoring and analyzing sensed conditions	US7877234B1	01/25/2011
System and method for statistically monitoring and analyzing sensed conditions	US7865336B1	01/04/2011
System and method for statistically monitoring and analyzing sensed conditions	US7865336B1	01/04/2011
Ion mobility spectrometer with virtual aperture grid	US7838823B1	11/23/2010
System and method for statistically monitoring and analyzing sensed conditions	US7756682B1	07/13/2010
System and method for statistically monitoring and analyzing sensed conditions	US7756682B1	07/13/2010
Microfluidic device for the assembly and transport of microparticles	US7744737B1	06/29/2010
Microfluidic device for the assembly and transport of microparticles	US7744737B1	06/29/2010
Dielectrophoretic columnar focusing device	US7713395B1	05/11/2010
Dielectrophoretic columnar focusing device	US7713395B1	05/11/2010
Method of photocatalytic nanotagging	US7704489B1	04/27/2010
Method of photocatalytic nanotagging	US7704489B1	04/27/2010
Correlation spectrometer	US7697134B1	04/13/2010
Nanoelectrode array for electrochemical analysis	US7625469B1	12/01/2009
Polymeric salt bridges for conducting electric current in microfluidic devices	US7618524B1	11/17/2009
Polymeric salt bridges for conducting electric current in microfluidic devices	US7618524B1	11/17/2009
Surface engineered nanoparticles for improved surface enhanced Raman scattering applications and method for preparing same	US7608461B1	10/27/2009
Surface engineered nanoparticles for improved surface enhanced Raman scattering applications and method for preparing same	US7608461B1	10/27/2009
Portable modular detection system	US7602307B1	10/13/2009
Complex admixtures of clathrate hydrates in a water desalination method	US7560028B1	07/14/2009
Complex admixtures of clathrate hydrates in a water desalination method	US7560028B1	07/14/2009
Complex admixtures of clathrate hydrates in a water desalination method	US7560028B1	07/14/2009
Microfluidic microarray systems and methods thereof	US7524672B2	04/28/2009
Microfluidic microarray systems and methods thereof	US7524672B2	04/28/2009
Detection of electrophilic and nucleophilic chemical agents	US7449579B1	11/11/2008
Correlation ion mobility spectroscopy	US7417222B1	08/26/2008
Method for detecting biomolecules	US7410762B1	08/12/2008
Method for detecting biomolecules	US7410762B1	08/12/2008
Stationary phase deposition based on onium salts	US7314505B1	01/01/2008
Stationary phase deposition based on onium salts	US7314505B1	01/01/2008
Stationary phase deposition based on onium salts	US7314505B1	01/01/2008
Method for siting detectors within a facility	US7308374B2	12/11/2007
Method for siting detectors within a facility	US7308374B2	12/11/2007
Electrokinetic pump	US7297246B2	11/20/2007
Electrokinetic pump	US7297246B2	11/20/2007
Enzymatic cascade bioreactor	US7264962B1	09/04/2007
Enzymatic cascade bioreactor	US7264962B1	09/04/2007
Enzymatic cascade bioreactor	US7264962B1	09/04/2007

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