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Self-assembly/disassembly of giant double-hydrophilic polymersomes at biologically-relevant pH

Shin, Sun H.; Mcaninch, Patrick T.; Henderson, Ian M.; Gomez, Andrew G.; Greene, Adrienne C.; Carnes, Eric C.; Paxton, Walter F.

Self-assembled giant polymer vesicles prepared from double-hydrophilic diblock copolymers, poly(ethylene oxide)-b-poly(acrylic acid) (PEO-PAA) show significant degradation in response to pH changes. Because of the switching behavior of the diblock copolymers at biologically-relevant pH environments (2 to 9), these polymer vesicles have potential biomedical applications as smart delivery vehicles.