Publications Details

Rapid Synthesis of Naphthol Derivatives through a Photocontrolled Exothermic Process

Xu, Zhenchuang; Bean, Ren H.; Hausladen, Matthew M.; Leguizamon, Samuel C.; Moore, Jeffrey S.; Appelhans, Leah N.

A photocontrolled isomerization reaction of oxabenzonorbornadiene (OBNBD) derivatives with a photo acid generator (PAG) has been developed. Under irradiation, the PAG releases an acid that catalyzes the heterolytic cleavage of the benzyl ether, triggering an aromatization process accompanied by substantial heat release that accelerates the transformation. Large exotherms can further push low reactivity substrates to achieve full conversion within minutes. This approach not only illuminates practical and environmentally benign advantages in organic synthesis but also opens new avenues for developing photoresponsive molecular architectures and advanced functional materials.