Publications Details

Screening for Dimerization Inhibitors for Bacterial Acetyl CoA Carboxylase

Kent, Michael S.; Sale, Kenneth L.; Ricken, James B.; Martinez, Daniella V.; Juarros, Miranda J.; Walrdop, Grover

The goal of this project was to develop compounds that kill biothreat bacteria by inhibiting the activity of bacterial acetyl CoA carboxylase (ACC) by blocking dimerization of one component of that enzyme complex, biotin carboxylase (BC). The ultimate goal is to combine a BC dimerization inhibitor with an existing active site inhibitor for carboxytransferase, another component of ACC, to form a new dual inhibitor therapy for this essential enzyme to avoid onset of resistance. Developing medical countermeasures to defeat antibiotic resistance in biothreat agents is of interest for national security for protecting both warfighters and the public.