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Programming Abstractions for Data Locality

Tate, Adrian; Kamil, Amir; Dubey, Anshu; Groblinger, Armin; Chamberlain, Brad; Goglin, Brice; Edwards, Harold C.; Newburn, Chris J.; Padua, David; Unat, Didem; Jeannot, Emmanuel; Hannig, Frank; Tobias, Gysi; Ltaief, Hatem; Sexton, James; Labarta, Jesus; Shalf, John; Fuerlinger, Karl; O'Brien, Kathryn; Linardakis, Leonidas; Besta, MacIej; Sawley, Marie-Christine; Abraham, Mark; Bianco, Mauro; Pericas, Miquel; Maruyama, Naoya; Kelly, Paul; Messmer, Peter; Ross, Robert B.; Ciedat, Romain; Matsuoka, Satoshi; Schulthess, Thomas; Hoefler, Torsten; Leung, Vitus J.

The goal of the workshop and this report is to identify common themes and standardize concepts for locality-preserving abstractions for exascale programming models.

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TYPE Other Report YEAR 2014
DOIOSTI

Enhanced densification under shock compression in porous silicon

Physical Review B - Condensed Matter and Materials Physics

Lane, James M.; Thompson, Aidan P.; Vogler, Tracy V.

Under shock compression, most porous materials exhibit lower densities for a given pressure than that of a full-dense sample of the same material. However, some porous materials exhibit an anomalous, or enhanced, densification under shock compression. We demonstrate a molecular mechanism that drives this behavior. We also present evidence from atomistic simulation that silicon belongs to this anomalous class of materials. Atomistic simulations indicate that local shear strain in the neighborhood of collapsing pores nucleates a local solid-solid phase transformation even when bulk pressures are below the thermodynamic phase transformation pressure. This metastable, local, and partial, solid-solid phase transformation, which accounts for the enhanced densification in silicon, is driven by the local stress state near the void, not equilibrium thermodynamics. This mechanism may also explain the phenomenon in other covalently bonded materials.

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TYPE Journal Article YEAR 2014
DOIOSTIScopus

Regulation and Function of Adult Neurogenesis. From Genes to Cognition

Physiological Reviews

Aimone, James B.

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. Our review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. Furthermore, the increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.

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TYPE Journal Article YEAR 2014
OSTIDOI
Results 5851–5900 of 9,998
Results 5851–5900 of 9,998