Neuron Simulation and Analysis with Xyce
Abstract not provided.
Publications
Neuroscience to Applications - Computational Neuroscience at Sandia National Laboratories
Abstract not provided.
Perspectives for computational modeling of cell replacement for neurological disorders
Frontiers in Computational Neuroscience
Mathematical modeling of anatomically-constrained neural networks has provided significant insights regarding the response of networks to neurological disorders or injury. A logical extension of these models is to incorporate treatment regimens to investigate network responses to intervention. The addition of nascent neurons from stem cell precursors into damaged or diseased tissue has been used as a successful therapeutic tool in recent decades. Interestingly, models have been developed to examine the incorporation of new neurons into intact adult structures, particularly the dentate granule neurons of the hippocampus. These studies suggest that the unique properties of maturing neurons, can impact circuit behavior in unanticipated ways. In this perspective, we review the current status of models used to examine damaged CNS structures with particular focus on cortical damage due to stroke. Secondly, we suggest that computational modeling of cell replacement therapies can be made feasible by implementing approaches taken by current models of adult neurogenesis. The development of these models is critical for generating hypotheses regarding transplant therapies and improving outcomes by tailoring transplants to desired effects.
A Hypothesis for Temporal Coding of Young and Mature Granule Cells
Proposed for publication in Frontiers in Neurogenesis.
Abstract not provided.
Simulating neural systems with Xyce
Sandia
Neurons to Algorithms neural circuit model development platform
Abstract not provided.
The value of looking deeper? the what why and how of high fidelity adult neurogenesis modeling
Abstract not provided.
Pattern separation or Pattern Resolution - A critical look at DG and neurogenesis function
Abstract not provided.
Adult Hippocampal Neurogenesis - Role in Learning and Memory
Abstract not provided.
Results 176–184 of 184