Creating novel tools for detecting and fighting disease


Infectious diseases and bioterrorism events may seem like very different phenomena—but both share enormous potential to threaten human health and economic stability. To protect the nation and world from these dangers, Sandia researchers conduct basic and applied research in host-pathogen interactions and countermeasures, including medical diagnostics, therapeutics, and vaccines.

Biology of Pathogens and Host-Pathogen Interactions: Creating knowledge to counter disease

Sandia conducts research into how pathogens interact and subvert a host’s immune response to develop the knowledge base needed to create new novel environmental detectors, medical diagnostics systems, therapeutics, and vaccines to counter natural or human-made outbreaks.

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    Employing Sandia-developed cutting-edge tools to probe and analyze the molecular events involved in host-pathogen interaction, Sandia researchers are advancing research in multiple critical areas:

    • Performing second generation sequencing to identify genomic pathogenic signatures in complex clinical matrices
    • Conducting studies to improve understanding of the biology of pathogens
    • Elucidating the interactions of pathogens with the host and the environment
    • Developing methods of analyzing and characterizing pathogens in clinical samples and tissues
    • Creating models to capture multi-omic data (or data from genomics, proteomics, and metabolomics) to build interaction networks

Countermeasure Deployment

Applying new knowledge of pathogen-host interactions, Sandia researchers are developing fully integrated devices for detecting bioagents in clinical samples, automated platforms for sample preparation, and engineered nanoparticles as nanodelivery platforms for vaccine and antibiotics. Many of our patented (and patent-pending) innovations have been licensed to companies for development of commercial devices and vaccines.