Achyuthan engages in research and development of chemical and biological sensors using volatile organic compounds as markers of chemical vapors, biological organisms, and disease diagnostics.
Anthony's research focuses on developing and applying quantitative imaging and multivariate analysis tools to study the spatio-temporal relationships that underlie key biological processes.
Branch's research interests include: micro and nanosystems for chemical and biological analysis and sensing, neurological interfaces, adaptive biological interfaces, acoustic wave biosensors and actuators, surface acoustic wave modeling, quartz resonator modeling, computational acoustics, piezoelectric materials, tunable materials and characterization, sensor arrays and pattern recognition, RF sensor systems.
Senior Manager, Applied Biosciences & Engineering
The Applied Bioscience & Engineering group at Sandia has expertise in microbiology, virology, phycology, molecular biology, bioinformatics, engineering, and modeling. The multidisciplinary team addresses a number of key problems impacting national security, including algal biomass fuel and chemical development, biodefense and emerging infectious disease, and real-time health and performance monitoring.
Branda is a microbiologist and molecular geneticist with extensive experience in characterization of bacterial pathogens and their interactions with the host.
Butler's research intersects nanomaterials, biology, genetics, genome editing, and novel imaging modalities.
Combs explores modes of human performance enhancement within multiple domains including the use of physiological metrics, visual inspection performance, and hacking behaviors - specializing in wearable devices.
Forrer develops and supports the Experiment Data Depot, a software repository of standardized biological experimental data and metadata. He works with cross-functional teams of scientists and engineers to both learn about and support science using his software engineering skills.
Geiselman engineers microorganisms to produce different industrially-relevant molecules of interest that will improve the bioeconomy by decreasing the cost and time of establishing said bioproducts.
Gladden develops technologies for the efficient deconstruction of biomass into fermentable sugars for conversion into biofuel. He also develops expression systems for high-titer enzyme production.
Harmon has extensive experience in drug discovery, virology, immunology, gene editing, molecular biology, high throughput screening, assay development, and bio-detection technology assessment. Her current research is focused on the development and use of biochemical and cell-based assays to discover novel small molecule and antibody therapeutcis for emerging viruses and other evolving biodefense targets.
Kent researchers cellulose and lignin breakdown using catalysts and enzymes. He also studies protein structure, enzymology, antibiotics, viruses, and therapeutic antibodies.
Kirby's research interest is primarily metabolic engineering of microbes for the sustainable production of bioproducts. He is particularly interested in terpenes and the fungus Rhodosporidium toruloides.
Raga Krishnakumar's main area of research is detecting, understanding, and regulating mammalian cell fate, including fate changes with response to environmental stimuli such as infectious agents or stress conditions.
Meagher's main research interest is the development of novel techniques and devices for nucleic acid analysis, particularly applied to problems in infectious disease, biodefense, and microbial communities. Most recently this has led to approaches for simplified molecular diagnostics for emerging viral pathogens which are suitable for use at the point-of-need or in the developing world.
Miller is interested studying biological systems via creation of devices/sensor systems capable of providing new insight into these hard to decipher physiological processes. Some of his recent work includes the development of microneedle sensors for monitoring stress in plants and ingestible capsules for sample collection in the GI tract.
Monroe's research focuses on whole-systems approaches to biofuel and bioproduct technologies with an emphasis on algae cultivation and conversion. His research research has a wide scope but tends to focus on research and development that have direct impacts on the food/energy/water nexus.
Moorman’s work focuses on MEMS chemical sensor development and the system-level packaging of chemical analysis systems and components. His recent work has focused on detecting and characterizing the volatile organic compounds produced by bacteria, plants, and algae.
Morrell's work focuses on laboratory data management systems, applying information technology to facilitate collaboration, analysis, archives, and reproducibility. This work includes both writing custom software and integrating it with existing software, working on the Internet, instrument controller workstations, servers, and personal computers.
Negrete is a virologist with a special interest in emerging viruses and a focus on molecular viral-host interactions. His research uses a broad spectrum of cellular, molecular biology, functional genomics, and nanoscience techniques to dissect host pathways involved in virus replication and deliver anti-viral cargos using nanoparticles.
Ngyugen is a computer software engineering technologist who has developed an agent-based predator-prey model to demonstrate the relationship between algae cultures and rotifers. He is also developing a user interface for existing chemical retrosynthesis software as well as integrating existing software and growth models to model the growth of algae and grazers under varying environmental conditions.
Parchert's current research examines the interaction of virus and host cell components. The aim of this research is to develop innovative viral diagnostic strategies utilizing these host-pathogen interactions.
Pfeifer's research interests include high-performance radiation and explosives detection, electrostatic discharge mechanisms and mitigation, surface plasmon resonance sensors, acoustic-based sensors, ion mobility spectroscopy, and holographic correlation spectroscopy.
Polsky's research activities are focused on the fundamental principles and fabrication of devices related to chemical and biological sensors.
Kunal’s work at Sandia is mostly focused on the development of computational tools in biodefense, infectious diseases, microbiome, biomass/biofuel and microbial ecology. Kunal has also built software tools to analyze sequencing data and apply machine-learning techniques for RNA-seq, ChIP-seq, CLK-ChIP-seq, Tiling arrays, expression arrays, Metagenomics and Amplicon sequencing.
Rempe's current work focuses on theoretical studies and molecular simulations of solutions, polymers, and biomolecules. In addition to expanding basic science, insights from those studies inform synthesis of new materials for water purification, energy storage, gas (CO2) separations, new molecules for cancer treatment, and antimicrobials.
Ruffing researches cyanobacteria and algae for biofuel production. She applies metabolic engineering and synthetic biology approaches to the development of novel biotechnologies for national security applications.
Sale's expertise is in structural and computational biology, enzymology, enzyme engineering, EPR spectroscopy, statistics, and data analytics.
Sammon's research concentrates on the development of microsensors, micro-gas chromatography, and chemical instrumental analysis. He also researches different methods to collect chemical samples for analysis and develop unique solutions to chemical sampling and analysis issues in various field environments.
Smallwood has a broad area of expertise in research areas such as cellular receptor binding, uptake, signaling, and expression; metabolic pathway modeling and engineering; high-throughput bio- and chemical imaging and detection using micro devices; multi-omics; bioproduction of high value chemicals and materials; photosynthetic systems physiology; microbial cellular physiology; and cellular mechanisms of drug and antibiotic resistance.
Timlin's research develops and applies novel advanced imaging and spectroscopic-based tools in conjunction with multivariate image analysis to understand the fundamental spatial-temporal relationships that govern complex biological processes.
Tran-Gyamfi studies plants, algae, fungi and yeast and has been able to understand the complexities and the roles that differing organisms can play in bioenergy. She works in the bioconversion of algal carbohydrate and proteins, engineers and screens yeast to produce terpenes, and runs algae testbed experiments.
Manager, Biotechnology and Bioengineering
The Biotechnology and Bioengineering team has expertise in micro and molecular biology, virology, analytical chemistry, microfluidics, and engineering. The diverse team addresses a number of key problems affecting national security, including algal and lignocellulosic biomass conversion, biodefense and emerging infectious disease, and real-time health and performance monitoring.
Whiting uses GC and GCxGC tools to advance chemical sensing. He is applying those technologies and others he has developed to increase Sandia's knowledge of complex volatile organic compounds produced by biological organisms.
Williams' studies how pathogenic bacterial genomes evolve. One of his software tools examines the numerous DNA mobility events that can occur in different subpopulations of a single overnight culture. Other software precisely maps mobile genomic islands and transposons.