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Stephen D. Bond

Citation:

Yuhui Cheng, Jason K. Suen, Zoran Radić, Stephen D. Bond, Michael J. Holst and J. Andrew McCammon, Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models, Biophysical Chemistry 127:3 (2007) 129-139.

Abstract:

The reaction-diffusion system of the neuromuscular junction has been modeled in 3D using the finite element package FEtk. The numerical solution of the dynamics of acetylcholine with the detailed reaction processes of acetylcholinesterases and nicotinic acetylcholine receptors has been discussed with the reaction-determined boundary conditions. The simulation results describe the detailed acetylcholine hydrolysis process, and reveal the time-dependent interconversion of the closed and open states of the acetylcholine receptors as well as the percentages of unliganded/monoliganded/diliganded states during the neuro-transmission. The finite element method has demonstrated its flexibility and robustness in modeling large biological systems.

Full Text:

DOI: 10.1016/j.bpc.2007.01.003

PMID: 17307283

Preprint:

Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models (2.0M, PDF)

Bibtex:
@article{CSRB2007,
  author  = {Yuhui Cheng and Jason K. Suen and Zoran Radi\'c and Stephen D.
             Bond and Michael J. Holst and J. Andrew McCammon},
  title   = {Continuum simulations of acetylcholine diffusion with
             reaction-determined boundaries in neuromuscular junction models},
  journal = {Biophysical Chemistry},
  volume  = 127,
  number  = 3,
  year    = 2007,
  pages   = {129--139},
  doi     = {10.1016/j.bpc.2007.01.003},
  pubmed  = 17307283
}

Stephen Bond