skip to: onlinetools | mainnavigation | content | footer

Stephen D. Bond

Citation:

Kaihsu Tai, Stephen D. Bond, Hugh R. MacMillan, Nathan Andrew Baker, Michael Jay Holst and J. Andrew McCammon, Finite Element Simulations of Acetylcholine Diffusion in Neuromuscular Junctions, Biophysical Journal 84 (2003) 2234-2241.

Abstract:

A robust infrastructure for solving time-dependent diffusion using the finite element package FEtk has been developed to simulate synaptic transmission in a neuromuscular junction with realistic postsynaptic folds. Simplified rectilinear synapse models serve as benchmarks in initial numerical studies of how variations in geometry and kinetics relate to endplate currents associated with fast-twitch, slow-twitch, and dystrophic muscles. The flexibility and scalability of FEtk affords increasingly realistic and complex models that can be formed in concert with expanding experimental understanding from electron microscopy. Ultimately, such models may provide useful insight on the functional implications of controlled changes in processes, suggesting therapies for neuromuscular diseases.

Full Text:

DOI: 10.1016/S0006-3495(03)75029-2

PMID: 12668432

Preprint:

Finite Element Simulations of Acetylcholine Diffusion in Neuromuscular Junctions (4.0M, PDF)

Bibtex:
@article{TBMB2003,
  author  = {Kaihsu Tai and Stephen D. Bond and Hugh R. MacMillan and Nathan
             Andrew Baker and Michael Jay Holst and J. Andrew McCammon},
  title   = {Finite Element Simulations of Acetylcholine Diffusion in
             Neuromuscular Junctions},
  journal = {Biophysical Journal},
  volume  = 84,
  year    = 2003,
  pages   = {2234--2241},
  doi     = {10.1016/S0006-3495(03)75029-2},
  pubmed  = 12668432
}

Stephen Bond