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Research in Microfluidics 

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Research in Microfluidic Transport at Sandia National Laboratories

Victoria VanderNoot, PhD.

Victoria VanderNoot
Victoria VanderNoot

Analytical Chemist

Senior Member of Technical Staff,
Biosystems Research Department

Biographical

I received both a B.Sc. in chemistry and a Ph.D. in analytical chemistry from Carleton University in Canada. I then moved to the University of Colorado Health Sciences Center, where I held a joint academic/industrial postdoctoral position that was sponsored by Monsanto Corporation. Afterwards, I took a two-year postdoctoral position at the University of Iowa working jointly between the Departments of Medicinal & Natural Product Chemistry and Chemical & Biochemical Engineering. I joined Sandia National Laboratories in 1998 and am currently a principal member of technical staff.

Current Research Interests

My research interests focus on biochemical and bioanalytical methods for environmental, biomedical, and biodefense applications with an emphasis on optical, microfluidic, and biosensor technologies. A key component of my work in recent years has focused on adapting microfluidic systems, including Sandia’s µChemLab™ platform, to fieldable devices that incorporate automated sample preparation to allow the devices to operate autonomously in remote locations.

I served as principal investigator (PI) in a cooperative research and development agreement with Tenix to develop the unattended water sensor (UWS), a fully automated, microfluidic system that monitors domestic water for protein toxins. We plan to extend the UWS’s capabilities to other water-relevant analytes, including microorganisms (e.g., E. coli, Cryptosporidia, and Giardia) and freshwater toxins, such as the microcystins. In addition, from August 2006 to July 2007, I received funding through the National Oceanic and Atmospheric Administration’s Cooperative Institute for Coastal and Estuarine Environmental Technology to develop electrophoretic methods for marine toxins.

I have been heavily involved with developing and testing technologies for aerosol- and aqueous-based monitoring for bacterial agents and toxins. This effort, which was funded by the U.S. Department of Defense (DoD), resulted in a fully automated platform for monitoring aerosol-borne microbial agents that participated in in situ testing of prototypes at DoD facilities.

Additional work has expanded on the theme of agent detection by developing methods for (1) quickly detecting spores by analyzing small acid-soluble proteins, (2) rapidly determining viability through the analysis of early germination de novo protein synthesis in a microfluidic approach, and (3) resolving intact spores and bacteria via electrophoretic methods.

I also served as co-PI on a project funded by the National Institutes of Health, or more specifically, the National Institute of Dental and Craniofacial Research. This project developed electrophoretic methods and the Integrated Microfluidic Platform for Oral Diagnostics (IMPOD), an integrated platform for determining disease biomarkers in saliva and other oral fluids.

Selected Publications and Presentations

For more information, contact: Victoria VanderNoot