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Ying-Chih Wang, Ph.D.

Biosystems Research and Development Department

Research Interests

My research activities focus on developing new point of care diagnostic systems and understanding complex micro/nanoscale biological transport phenomenon. In one recent project, our team use on-chip photo-polymerization as a tool to integrate multiple sample preparation steps into a seamless microfluidic platform. The platform, also known as micro total analysis systems (mTAS), will be used for rapid (<10 min) and ultra sensitive (sub-pM) biotoxin and biomarker detection. To further reduce the analysis time without compromising the sensitivity, I am currently working on strategies to increase the throughput of the device. I am also developing low cost disposable platforms by novel polymerization approaches.

Recent Publications

Wang, Y-C, AK Singh, AV Hatch. (2008). Ultra-rapid sample preconcentration under slant field using high-aspect-ratio nanoporous membranes. Proceedings of MicroTAS 2008, The Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Diego, CA. October 12–16.

Y.-C Wang and J. Han. “Pre-binding Dynamic Range and Sensitivity Enhancement for Immuno-sensors Using Nanofluidic Preconcentrator.” Lab on a Chip, 2008, 8(3), 392-394.

S.J. Kim*, Y.-C. Wang*, J.H. Lee, H. Jang, and J. Han. “Concentration Polarization and Nonlinear Electrokinetic Flow near Nanofluidic Channel.” Physical Review Letters, 2007, 99, 044501.

Y.-C. Wang and S. H. Chang. “Design and Performance of a Piezoelectric Actuated Precise Rotary Positioner.“ Review of Scientific Instruments, 2006, 77, 105101.

Y.-C. Wang, A.L. Steven and J. Han. “Million-fold Preconcentration of Proteins and Peptides by Nanofluidic Filter.” Analytical Chemistry, 2005, 77 (14); 4293-4299.

Y.-C. Wang, M.H. Choi, and J. Han. “Two-Dimensional Protein Separation with Advanced Sample and Buffer Isolation Using Microfluidic Valves.” Analytical Chemistry, 2004, 76 (15); 4426-4431.

Patents

“Integrated Microfluidic Device for Preconcentration and Detection of Multiple Biomarkers”, International Patent Pending, WO 2008/043040

“Device for Mixing and Delivering Fluids for Tissue Repair”, International Patent Pending, WO 2006/086479

“Electrokinetic Concentration Device and Methods of Use Thereof”, US Patent Pending, US 2006/0180469

Appointments

2008–present: Postdoctoral Fellow, Sandia National Laboratories, Livermore CA

Education

2004-2007: Ph.D., Dept. of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA

2002-2004: M.S., Dept. of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA

1996-2000: B.S., Dept. of Mechanical Engineering, National Taiwan University, Taipei, Taiwan

Contact Information

Dr. Ying-Chih Wang
Biosystems Research Department
Sandia National Laboratories
MS 9291, PO Box 969
7011 East Avenue
Livermore, CA 94551-0969
ycwang@sandia.gov
phone: 925-294-6351
fax: 925-294-3020