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Victoria VanderNoot, Ph.D.

Analytical Chemist
Senior Member of Technical Staff,
Biosystems Research and Development Department

Victoria VanderNoot, Ph.D photo

Biographical

I received both a B. Sc. (Chemistry) and a Ph. D. (Analytical Chemistry) from Carleton University in Canada. From there I went to the University of Colorado Health Sciences Center for a joint academic/industrial post-doctoral position (with Monsanto Corp.) and from there to the University of Iowa for a two year post-doctoral position working jointly between the Depts. of Medicinal & Natural Product Chemistry and Chemical & Biochemical Engineering.

I joined Sandia National Laboratories in 1998 and am currently a Principal Member of Technical Staff.

Current Research Interests

My research interests focus on biochemical and bioanalytical methods for environmental, biomedical, and biodefense applications with an emphasis on optical, microfluidic, and biosensor technologies. A key component of my work in recent years has focused on adapting microfluidic systems, including Sandia’s µChemLab™ platform, to fieldable devices that incorporate automated sample preparation to allow the devices to operate autonomously in remote locations.

I served as Principal Investigator (PI) in a Cooperative Research and Development Agreement with Tenix to develop a fully automated microfluidic monitoring system for protein toxins in domestic water known as the Unattended Water Sensor or UWS. We plan to extend the capabilities of the UWS to other water-relevant analytes including microorganisms such as E. coli, Cryptosporidia and Giardia as well as freshwater toxins such as the microcystins. Recently, I was funded through the National Oceanic and Atmospheric Administration’s Cooperative Institute for Coastal and Estuarine Environmental Technology (CICEET) to develop electrophoretic methods for marine toxins (August 2006 to July 2007).

I have been heavily involved with developing and testing technologies for aerosol- and aqueous-based monitoring for bacterial agents and toxins. This U.S. Department of Defense (DoD)-funded effort resulted in a fully automated platform for monitoring of aerosol-borne microbial agents that participated in in situ testing of prototypes at DoD facilities.

Additional work has expanded on the theme of agent detection in developing methods for rapid spore detection via analysis of small acid-soluble proteins; rapid determination of viability via analysis of early germination de novo protein synthesis in a microfluidic approach; and methods for resolving intact spores and bacteria via electrophoretic methods.

I also served as Co-PI on a National Institutes of Health (NIDCR - National Institute of Dental and Craniofacial Research) funded project that developed electrophoretic methods and an integrated platform for the determination of biomarkers of disease in saliva and other oral fluids known as the IMPOD (Integrated Microfluidic Platform for Oral Diagnostics)

Selected Publications and Presentations

Victoria VanderNoot, Elizabeth Van Blarigan, Deanna Curtis, Pamela Lane and Todd Lane. 122nd AOAC Annual Meeting & Exposition, September 21-24, 2008, Dallas, TX. HABLab: A Micro Fabricated Total Analytical System (uTAS) for Detecting Phytotoxins in Water.

Julia A. Fruetel, Jason A.A. West, Bert J. Debusschere, Kyle Hukari, Todd W. Lane, Habib N. Najm, Jose Ortega, Ronald F. Renzi, Isaac Shokair, Victoria A. VanderNoot, (2008), Rapid Identification of Viruses using Microfluidic Protein Profiling and Bayesian Classification, Analytical Chemistry, in press

Victoria VanderNoot, Brent Haroldsen,Wayne Einfeld and Yolanda Fintschenko, (2008), Unattended Water Sensor for Detection of Toxins in Water Systems, Environmental & Water Resources Institute Currents, 9, 6-7.

Victoria VanderNoot, Keynote Speaker; 28th Annual Meeting AOAC International Pacific Northwest Section, Tacoma, WA, June 18-19, 2008. Micro-Total Analytical Systems and other Field-capable Platforms: Challenges and Considerations.

Victoria VanderNoot, Deanna Curtis, Pamela Lane and Todd Lane. PacRim 2007, Pacific Rim Shellfish Conference, April 22-23rd, 2008, San Diego CA, Development of a Portable and Automated Electrophoresis Based System for in-field Toxin Detection: “HABLab”.

Pizarro, S.A., P. Lane, T.W. Lane, E. Cruz, B. Haroldsen, and V.A. VanderNoot. 2007. Bacterial characterization using protein profiling in an integrated microchip separations platform. Electrophoresis, 28, 4697–4704.

Stachowiak, J.C., E.E. Shugard, B.P. Mosier, R.F. Renzi, P.F. Caton, S.M. Ferko, J.L. Van de Vreugde, D.D. Yee, B.L. Haroldsen, and V.A. VanderNoot. 2007. Autonomous microfluidic sample preparation system for protein profile-based detection of aerosolized bacterial cells and spores. Analytical Chemistry 79: 5763–5770.

Victoria VanderNoot Department of Homeland Security, 2007 Homeland Security Conference, Monterey CA, August 21-24, 2007. Portable BioAgent Detection Systems for National Security Applications.

Fruetel, J.A., R.F. Renzi, V.A. VanderNoot, J. Stamps, B.A. Horn, J.A.A. West, S. Ferko, R. Crocker, C.G. Bailey, D. Arnold, B. Wiedenman, W.-Y. Choi, D. Yee, I. Shokair, E. Hasselbrink, P. Paul, D. Rakestraw, and D. Padgen. 2005. Microchip separations of protein biotoxins using an integrated hand-held device. Electrophoresis 26:1144–1154.

Renzi, R.F., J. Stamps, B.A. Horn, S. Ferko, V.A. VanderNoot, J.A.A. West, R. Crocker, B. Wiedenman, D. Yee, and J.A. Fruetel. 2004. Hand-held microanalytical instrument for chip-based electrophoretic separations of proteins. Analytical Chemistry 77:435–441.

Victoria VanderNoot et al.2nd National Conference on Environmental Sampling and Detection for Bio-Threat Agents held in New York City October 25-27th, 2006. Integrated and Automated Sample Preparation Systems for Aerosol and Water Monitoring Applications

V.A. VanderNoot, G.S. Chirica, J. Cintron, J.A.A. West J. Fruetel, T.W. Lane P.F. Caton K. Wally and B.L. Haroldsen.2nd Joint Conference on Point Detection for Chemical and Biological Defense, Williamsburg, VA, March 1-5, 2004. Detection of Bacterial Biowarfare Agents with a Proteomics-Based Analyzer

Victoria VanderNoot, Shelly Pizarro, Julie Fruetel, Ron Renzi, and Jamie Stamps, Phosphoprotein Signatures for Early Pathogen Exposure Detection Using µChemLab™, Mainstreaming Microfluidics, Boston, MA, May 15-16, 2003.

M. VanRollins and V.A. VanderNoot, Simultaneous Resolution of Underivatized Regioisomers and Stereoisomers of Arachidonate Epoxides by Capillary Electrophoresis Analytical Biochemistry, (2003), 313, 106-116.

Victoria VanderNoot, Boyd Wiedenman, Yolanda Fintschenko and Julie Fruetel, Incorporation of Sample Preconcentration into the µChemLab™/CB Platform for Enhanced Sensitivity, 16th International Symposium on Microscale Separations and Analysis (HPCE 2003), San Diego, CA, January 17-22, 2003.

Victoria A. VanderNoot and Mike VanRollins, Capillary Electrophoresis of Cytochrome P-450 Epoxygenase Metabolites of Arachidonic Acid. 2. Resolution of Stereoisomers Analytical Chemistry, (2002), 74, 5866-5870.

Victoria A. VanderNoot and Mike VanRollins, Capillary Electrophoresis of Cytochrome P-450 Epoxygenase Metabolites of Arachidonic Acid. 1. Resolution of Regioisomers Analytical Chemistry, (2002), 74, 5859-5865.

Julia A. Fruetel, Brent A. Horn, Jay A.A. West, James F. Stamps, Victoria A. VanderNoot, Mary Clare Stoddard, Ronald F. Renzi and Debbie Padgen, Results From µChemLab™/CB, A Portable System For Detecting Chemical And Biological Warfare Agents.µTAS 2002. Y. Babu, S. Shoji and A. van den Berg. ed.s, (Kluwer Academic, Dordrecht), (2002), pp. 524-526.

Ronald F. Renzi, James F. Stamp, Robert W. Crocker, Boyd J. Wiedenman, Scott M. Ferko, Brent A. Horn, Dan Yee, Victoria A. VanderNoot, Jason A. West, Julia A. Fruetel, Yolanda Fintschenko and Mary Clare Stoddard, Engineered Improvement of the Generation-2 µChemLab‘ Biotoxin Detector. µTAS 2002. Y. Babu, S. Shoji and A. van den Berg. ed.s, (Kluwer Academic, Dordrecht), (2002), pp. 703-705.

Shelly A. Pizarro, Joseph S. Schoeniger, Victoria A. VanderNoot. Capillary-Based Separation Microtechnologies For Pattern Profiling Of Phosphoproteins Involved In T-Cell Signaling. Microtechnologies in Medicine and Biology 2002 (IEEE-EMBS) Proceedings, A. Dittmar and D. Beebe, ed.s, (IEEE, Inc, Piscataway, NJ), (2002), pp.433-436.

Julia Fruetel, V. A. VanderNoot, Brian Kirby, Charlie Hasselbrink and Tim Shepodd Polymeric Coating Protocol for µChemLab/CB. 15th International Symposium on Microscale Separations and Analysis (HPCE 2002), Stockholm, Sweden, April 13-18, 2002.

Victoria A. VanderNoot, Emily Keuhler And Shelly Pizarro, Isoelectric Focusing With Laser-Induced Fluorescence Detection Of Phosphoprotein Signatures, 15th International Symposium on Microscale Separations and Analysis, (HPCE 2002), Stockholm, Sweden, April 13-18th, 2002.

VanderNoot VA, Hux G, Schoeniger J, Shepodd T. "Isoelectric Focusing Using Electrokinetically-Generated Pressure Mobilization". µTAS (2001). van den Berg, et al. ed.s, (Kluwer Academic, Amsterdam), pp. 127-128.

Fruetel J, Renzi R, Crocker R, VanderNoot V, Stamps J, Yee D, Rakestraw D, Paul P, Arnold D, Bailey, C. " µChemLab/CB: Parallel Channel Analysis in an Integrated Microchip Device." 14th International Symposium on Microscale Separations and Analysis (HPCE 2001), Boston, MA, January 13-18, 2001.

Fruetel, J.R., R.; Crocker, R.; VanderNoot, V.; Ferko, S.; Stamps, J.; Shokair, I.; Yee, D.; Hasselbrink, C., "Development Of µChemlab/CB For Detection Of Biotoxins". Proceedings of the First Joint Detection for Chemical and Biological Defense, (2000): p. 131-139.

VanderNoot VA, Volponi J, Hebbring S, Schoeniger JS. "Development and Characterization of Receptor Based Stationary Phases for Capillary Affinity Electrochromatography." Federation of Analytical Chemistry and Spectroscopy Societies Conference, Vancouver, B.C., Canada, October 25-29. 1999

Caldwell EE, Andreasen AM, Blietz MA, Serrahn JN, VanderNoot V, Park Y, Yu G, Linhardt RJ, Weiler JM."Heparin binding and augmentation of C1 inhibitor activity." Arch Biochem Biophys 361(2):215-22. 1999.

Fath M, VanderNoot V, Kilpelainen I, Kinnunen T, Rauvala H, Linhardt RJ. "Interaction of soluble and surface-bound heparin binding growth-associated molecule with heparin." FEBS Lett 454(1-2):105-8. 1999.

I. Capila, V.A. VanderNoot, T.R. Mealy, B.A. Seaton, R.J. Linhardt, Interaction of Heparin with Annexin V. FEBS Letters, (1999), 446, 327-330.

Lai EPC, Farfara A, VanderNoot VA, Kono M, Polsky B. "Surface Plasmon Resonance Sensors Using Molecularly Imprinted Polymers for Sorbent Assay of Theophylline, Caffeine and Xanthine." Canadian J Chem 76:265-273. 1998.

J. H. Choe, V. A. VanderNoot, R. J. Linhardt and J. S. Dordick, Affinity-based Reversed Micellar Extraction and Separation (ARMES) to Resolve Structurally Similar Glycoproteins. AICHE Journal, (1998), 44, 2542-2548.

VanderNoot VA, Hileman RE, Dordick JS, Linhardt RJ. "Affinity capillary electrophoresis employing immobilized glycosaminoglycan to resolve heparin-binding peptides." Electrophoresis 19(3):437-41. 1998.

VanderNoot VA, Dordick JS, Van Rollins M. " Capillary electrophoresis for the enantiomeric and regioisomeric resolution of fatty acid epoxides in biological samples." Federation of Analytical Chemistry and Spectroscopy Societies Conference, Providence, RI. October 26-30. 1997.

J. H. Choe, V. A. VanderNoot, R. J. Linhardt and J. S. Dordick, Parameters Affecting the Affinity Based Reversed Micellar Extraction and Separation of Glycoproteins. Biotechnology Progress, (1997), 13, 440-445.

C.L. Chakrabarti, B. Marchand, V. A. VanderNoot, J. Walker and W.H. Schroeder, Development Of A New Method For Direct Determination Of Selenium Associated With Atmospheric Particulate Matter Using Chemical Modifiers And Graphite Probe Furnace Atomic-Absorption. Spectrochimica Acta Part B-Atomic Spectroscopy, (1996), 51, 155-163.

VanderNoot VA, Fitzpatrick FA. "Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2." Anal Biochem 230(1):108-14. 1995.

Berg DA, VanderNoot VA, Barradas RG, Lai EPC. "In-Situ Photoacoustic Determination of Thallium Underpotential Deposition on Copper." J Electroanal Chem 369:33-37. 1994.

VanderNoot VA, Lai EPC. "Determination of Mercury (II) in Dithizone-impregnated Latex Microparticles by Photochromism-induced Photoacoustic Spectroscopy" Anal Chem 64:3187-3190. 1992.

VanderNoot VA, Lai EPC. "Detecting Surface Plasmon Resonance Using Photothermal Deflection Spectroscopy: Development of an Optical Immunosensor." Spectroscopy 6(7):28-33. 1991.

For More Information Contact: Victoria VanderNoot