Nimisha Srivastava, Ph.D.

I am interested in using and developing microfluidics as an integrated and automated tool for chemical and biomedical applications. Currently, I am developing multiplexed microfluidic assays to evaluate protein-protein interactions and protein phosphorylation states for studying host-pathogen response at single cell and small population levels.  Such microfluidic assays may then be integrated with downstream analysis such as a flow cytometer and cell sorter and thus provide a robust and unique engineering platform for evaluating cell signaling.

My other research interest involves developing a multiple shear rates generating microfluidic platform for analyzing the rheological properties of Newtonian and non-Newtonian body fluids such as whole blood, synovial fluid and saliva. In medical diagnostics, the viscosity of body fluids can uniquely predict or indicate disorders. For instance, blood viscosity is an early predictor of cardiovascular diseases, type 2 diabetes mellitus and retinopathy. The wide range of maladies that can be predicted by simply measuring the rheological properties of a body fluid indicates that a simple and inexpensive microfluidic rheology platform for that is widely available to patients and medical professionals will be very beneficial.

Recent Publications

Srivastava, N; Burns, MA. Electronic drop sensing in microfluidic devices: automated operation of a nanoliter viscometer.  Lab on a Chip; 2006; vol.6, no.6, p.744-51

Srivastava N. Burns M.A. ‘Electronic drop sensing in microfluidic devices: automated operation of a nanoliter viscometer’ Lab Chip: DOI 10.1039/b516317j 2006.

Srivastava N. Burns M.A. ‘Analysis of Non-Newtonian Liquids using a Microfluidic Capillary Viscometer’ Analytical Chemistry 78(5): 1690-1696, 2006.
PubMed

Srivastava N., Davenport R.D., Burns M.A. ‘A Nanoliter Viscometer for analyzing blood plasma and other liquid samples’ Analytical Chemistry 77(2): 383-392, 2005
PubMed

Pal R., Yang M., Lin R., Johnson B.N., Srivastava N., Razzacki Z., et al ‘An integrated microfluidic device for influenza and other genetic analyses’. Lab Chip, Cover Page, 5(10), 1024, 2005
PubMed

Ugaz V.M., Lin R., Srivastava N., Burke D.T, Burns M.A. ‘A versatile microfabricated platform for electrophoresis of double- and single-stranded DNA’. Electrophoresis,  24 (1-2), 151, 2003.
PubMed

Srivastava N., Roy A., Pant N., Bhaskarwar A.N. ‘Washing Kinetics of a novel pollution preventing ink’ Chemical Engineering Science 60: 1725-1731, 2005

Patents

Burns M.A, Srivastava N., Davenport R.D., ‘A novel viscometer’ PCT Application filed in the United States Patent and trademark office Sept 24, 2005.

Appointments

2006–Present—Postdoctoral Fellow, Sandia National Laboratories, Livermore CA

Education

Contact Information

Nimisha Srivastava, Ph.D.
Biosystems Research Department
Sandia National Laboratories
MS 9291, PO Box 969
7011 East Avenue
Livermore, CA 94551-0969

nsrivas@sandia.gov
phone: 925-294-2507
fax: 925-294-3020