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Rajiv Bharadwaj, Ph.D.
 

RESEARCH SUMMARY

A fusion of biology with the physical and engineering sciences is vital for future advances in biological and biomedical research. The development of novel instrumentation is a key ingredient towards advancing scientific research. I am particularly interested in technology development which exploits novel phenomena accessible at micro- and nano-scales. Currently, I am developing microfluidic devices for high throughput and sensitive bioanalysis to accelerate cost-effective generation of lignocellulosic biofuels. This work is being performed in collaboration with the Joint BioEnergy Institute (JBEI), Emeryville.  

I am also interested in development of integrated systems for clinical, genomic, and proteomic applications. Some examples of my past work include development of microfluidic liver cancer clinical diagnostic system, integrated sample prep and RT-PCR device for RNA/DNA analyses, and high-sensitivity label-free protein separations. My doctoral work focused on investigation of nonlinear electrokinetic (EK) phenomena pertaining to sample pre-concentration techniques. I remain interested in fundamental and applied aspects of in-vitro and in-vivo EK processes.

Employment

2008–present: Scientist, Sandia National Laboratories, Livermore, CA

2005–2008: Senior R&D Engineer, Caliper Life Sciences, Mountain View, CA        

Education

2001–2005: Ph.D. Chemical Engineering, Stanford University, Stanford, CA
Advisor: Prof. Juan G. Santiago

1999–2001: M.S. Chemical Engineering, Stanford University, Stanford, CA

1995–1999: B.Tech. Chemical Engineering, Indian Institute of Technology, New Delhi, India

RECENT PUBLICATIONS

Bharadwaj, R., C. Park, I. Kazakova, H. Xu, and J. Paschkewitz, “Non-Equilibrium Capillary Electrophoresis of a-Fetoprotein Isoforms,” Analytical Chemistry, 80, 129-134, 2008

Paschkewitz, J., J. I. Molho, H. Xu, R. Bharadwaj, and C. Park, “Turn-Induced Isotachophoretic Focusing in Microfluidic Channels,” Electrophoresis, 28, 4561-4571, 2007.

Devasenathipathy, S., R. Bharadwaj, and J. G. Santiago, “Investigation of Internal Pressure Gradients Generated in Electrokinetic Flows with Axial Conductivity Gradients,” Experiments in Fluids, 43, 959-967, 2007.

Jung, B., R. Bharadwaj, and J.G. Santiago, “On-chip Millionfold Sample Stacking Using Transient Isotachophoresis,” Analytical Chemistry, 78, 2319-2327, 2006.

Bharadwaj, R., and J.G. Santiago, "Dynamics of Field Amplified Sample Stacking," Journal of Fluid Mechanics, 543. 57-92, 2005. 

Alexis-Alexandre, G., B. Mohammadi, J.G. Santiago, and R. Bharadwaj, “Microfluidic Flow Simulation: Stacking One-Dimensional Study,” Houille Blanche-Revue Internationale De L Eau, No. 5, 18-23, 2003.

Jung, B., R. Bharadwaj, and J.G. Santiago, “Thousand-Fold Signal Increase using Field Amplified Sample Stacking for On-Chip Electrophoresis,” Electrophoresis, Vol. 24, No. 19-20, 3476-3483, 2003. 

Bharadwaj, R., J.G. Santiago, and B. Mohammadi, "Design and Optimization of On-Chip Capillary Electrophoresis," Electrophoresis (invited paper), Vol. 23, 2729-2744, 2002.

 

BOOK CHAPTERS

R. Bharadwaj, D. E. Huber, T. Khurana, and J.G. Santiago, “Taylor Dispersion in Sample Pre-Concentration Methods,” CRC Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third ed.; CRC Press: New York, Ed. James P. Landers, 2007.

PATENTS

Santiago J.G., B. Jung, and R. Bharadwaj, "Microfluidic Sample Stacking Method Using Single-Interface Isotachophoresis," Provisional Application No. S05-338(STFD.128P1), 2006.

Contact Information

Dr. Rajiv Bharadwaj
Biosystems Research Department
Sandia National Laboratories
MS9291, PO Box 969
7011 East Avenue,
Livermore, CA 94551-0969

rbharad@sandia.gov
phone: 925-294-1083
fax: 925-294-3020