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Aarthi Chandrasekaran, Ph.D.

 

Research Summary

My current research work in the technologies division at the Joint BioEnergy Institute (JBEI), Emeryville, focuses on the development of enzyme assays for biofuels research. Our goal is to develop novel platforms for high throughput expression and functional characterization of enzymes.

My other interests include development of new technologies to study the mechanisms of host-pathogen interactions. My graduate research focused on investigating the role of glycans in mediating host-pathogen interactions. Towards this, I identified and characterized the glycans expressed on the surface of human epithelial cells and tissues and studied their interactions with bacterial toxins and viral coat proteins. Our studies led to the identification of the glycan determinant required for the human adaptation of avian influenza A viruses. Other projects that I have worked on include examination of the role of the extracellular matrix in stem cell differentiation and development of devices for label-free detection of heparin.

Selected Publications

Viswanathan K, Chandrasekaran A, Srinivasan A, Raman R, Sasisekharan V, Sasisekharan R. Glycans as Receptors for Influenza Virus Pathogenesis. 8th ICSM Proceedings, Glycoconjugate Journal. Submitted.

Srinivasan A*, Viswanathan K*, Raman R*, Chandrasekaran A*, Raguram S, Tumpey TM, Sasisekharan V, Sasisekharan R. Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses. Proceedings of the National Academy of Sciences U S A. 2008 Feb 26;105 (8):2800-5. [* Equal Contributors]

Chandrasekaran A*, Srinivasan A*, Raman R*, Viswanathan K*, Raguram S, Tumpey TM, Sasisekharan V, Sasisekharan R. Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin. Nature Biotechnology. 2008 Jan; 26(1):107-13. [* Equal Contributors]

Milovic NM, Behr JR, Godin M, Hou CS, Payer KR, Chandrasekaran A, Russo PR, Sasisekharan R, Manalis SR. Monitoring of heparin and its low-molecular-weight analogs by silicon field effect. Proceedings of the National Academy of Sciences U S A. 2006 Sep 5; 103 (36):13374-9.

Patents:

Sasisekharan R, Viswanathan K, Chandrasekaran A, Raman R, Srinivasan A, S Raguram, V Sasisekharan. Hemagglutinin polypeptides, and reagents and methods relating thereto. International Patent Pending: WO/2008/073161.

Manalis S, Loh TL, Godin M, Milovic NM., Behr JR, Chandrasekaran A, Sasisekharan R. Monitoring heparin by microelectronic devices. US Patent Application Pending: 20070212786.

Sengupta S, Sasisekharan R, Keiser N, Eavarone D, Kiziltepe TB, Chandrasekaran A, Berry DA, Holley K. Methods and compositions related to modulating the extracellular stem cell environment. International Patent Application Pending WO/2006/076627.

Chandrasekaran A, Sengupta S, Berry DA., Holley K, Zhao G, Sasisekharan R. Methods and compositions related to the modulation of intercellular junctions. International Patent Application Pending WO/2006/088491.

Appointments:

2009 – Present: Postdoctoral Appointee (JBEI), Sandia National Laboratories, Livermore, CA

Education:

2002-2008: Ph.D., Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA
1998-2002: B.Tech., National Institute of Technology, Warangal, India

Contact Information

Aarthi Chandrasekaran, Ph.D.
5885 Hollis Street
Fourth Floor
Emeryville, CA 94608

achandrasekaran@lbl.gov
achandr@sandia.gov
Ph: 510-495-2940